BRCA1 Represses Amphiregulin Gene Expression
نویسندگان
چکیده
منابع مشابه
BRCA1 represses amphiregulin gene expression.
BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and revealed a number of genes regulated by BRCA1 on the level of transcription. Among the genes repres...
متن کاملSly Represses Gene Expression in Sex Chromosomes
The nuclei of eukaryotic cells can be thought of as a library containing the molecular ‘‘recipes,’’ or genes, for constructing the proteins and ribonucleic acid molecules used by a cell. Within the library, genes are grouped together into ‘‘books,’’ known as chromosomes, which consist of linear strands of DNA wrapped around specialized DNA-interacting proteins. Human body cells have 46 chromoso...
متن کاملUninterrupted Sedentary Behavior Downregulates BRCA1 Gene Expression.
BRCA1 mutation carriers face a high lifetime risk of developing breast cancer. Physical activity induces broad transcriptional changes, and multiple studies have documented its beneficial effects across cancers. Because haploinsufficiency predisposes to breast cancer in these women, factors that increase BRCA1 levels may mitigate the effect of the mutation. Whether physical activity modulates B...
متن کاملBRCA1 regulates p53-dependent gene expression.
Mutations in BRCA1 are present in 45% of families that segregate with susceptibility for breast cancer and in 80-90% of families with both breast and ovarian cancer. Here we report that BRCA1 stimulates artificial and genomic promoter constructs containing p53-responsive elements. This activity of BRCA1 depends on the presence of wild-type p53, which was shown by using mouse fibroblasts express...
متن کاملTranscription factor c-Jun activation represses mdr-1 gene expression.
Expression of mdr-1 is complex and highly regulated. Several lines of evidence indirectly suggest that transcription factor c-Jun may negatively regulate human mdr-1 gene expression. We recently found that salvicine, a novel topoisomerase II inhibitor, is cytotoxic for multidrug resistance (MDR) tumor cells and down-regulates mdr-1 expression in MDR K562/A02 cells. Salvicine also stimulates a s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-2842